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Updated: Jun 6, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Disseminated herpes simplex virus type 1 primary infection in a healthy individual
Guy Boivin1, Brigitte Malette, Nathalie Goyette
1Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Québec;
Background:
Primary herpes simplex virus (HSV) infection usually involves one mucosal region.
Objective:
To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man.
Results:
Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain.
Conclusion:
Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.
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