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Left ventricular hypertrophy, geometric patterns and clinical correlates among treated hypertensive Nigerians

Adeseye Akintunde1, Olayinka Akinwusi, George Opadijo

  • 1Division of Cardiology, Department of Internal Medicine, LAUTECH Teaching Hospital, Osogbo, Osun State, Nigeria.

The Pan African Medical Journal
|December 2, 2010
PubMed

Insights

Concentric remodeling is the most common left ventricular geometric pattern in hypertensive individuals. This pattern, along with other left ventricular geometries, is linked to chamber and wall dimensions, impacting cardiovascular risk.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Left ventricular hypertrophy (LVH) is a significant cardiovascular risk factor, often associated with hypertension.
  • Hypertension can lead to diverse left ventricular geometric patterns, influencing patient risk profiles.
  • Understanding these patterns is crucial for managing hypertensive individuals.

Purpose of the Study:

  • To investigate the prevalence of different left ventricular geometric patterns in hypertensive subjects.
  • To explore the association between hypertension duration and left ventricular geometry.
  • To determine the relationship between left ventricular geometry and cardiac dimensions.

Main Methods:

  • Echocardiography was used to diagnose left ventricular hypertrophy and assess cardiac dimensions in 188 hypertensive patients.
  • Relative wall thickness was calculated using the formula: 2 × PWT/LVIDd.
  • Statistical analysis was performed using SPSS 15.0, categorizing subjects by hypertension duration.

Main Results:

  • Concentric remodeling was the most frequent left ventricular geometric pattern, followed by normal geometry.
  • Hypertension duration exceeding 5 years correlated with older age, lower ejection fraction, and larger left ventricular diastolic dimensions.
  • Left ventricular geometry was primarily associated with left ventricular chamber and wall dimensions.

Conclusions:

  • Concentric remodeling represents the predominant left ventricular geometric pattern in hypertensive patients.
  • Left ventricular geometry is significantly associated with cardiac chamber and wall dimensions.
  • Eccentric hypertrophy, though rare, indicates the poorest left ventricular systolic function and may precede progressive systolic impairment.
Abstract

Keywords:
Nigeriaclinical correlateshypertensionleft ventricular geometry

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