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Related Experiment Video

Updated: Jun 6, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

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Natural glycoconjugates with antitumor activity.

Barbara La Ferla¹, Cristina Airoldi, Cristiano Zona

¹Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I-20126, Milano, Italy. francesco.nicotra@unimib.it

Natural Product Reports

|December 2, 2010

Summary

Natural glycosides are promising anticancer agents. This review classifies these compounds by their aglycone structure, detailing their mechanisms against human tumors and potential for new drug development.

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Area of Science:

Natural Products Chemistry
Medicinal Chemistry
Pharmacology

Background:

Cancer remains a leading global cause of mortality, driving the search for novel therapeutic strategies.
Glycosylated natural products demonstrate significant antimicrobial and anticancer activities.
The role of glycosylation in drug efficacy, solubility, and pharmacokinetics is increasingly recognized.

Purpose of the Study:

To review and classify natural glycosides with anticancer properties based on their aglycone structure.
To elucidate the mechanisms of action and structure-activity relationships of these compounds against human cancers.
To highlight the potential of natural glycoconjugates in the development of new anti-tumor drugs.

Main Methods:

Classification of glycosides based on the aglycone moiety.
Description of specific classes: anthracyclines, aureolic acids, enediyne antibiotics, macrolides, and glycopeptides.
Analysis of the role of carbohydrate structures and their impact on biological activity and drug properties.

Main Results:

Natural glycosides exhibit diverse anticancer mechanisms and potencies.
The glycosidic residue is essential for the activity of some compounds (e.g., anthracyclines, aureolic acids, enediynes).
Glycosylation enhances solubility and pharmacokinetic profiles in other compounds (e.g., glycopeptides).

Conclusions:

Natural glycoconjugates represent a valuable resource for anticancer drug discovery.
Understanding the structure-activity relationships and biological interactions is key for designing novel anti-tumor agents.
Further research into these compounds can lead to the development of more effective cancer therapies.