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Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates
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Kikuchi-Fujimoto disease: three case reports.

Alexandre de Andrade Sousa1, João Marcos Arantes Soares, Marco Homero de Sá Santos

  • 1Instituto Alfa de Gastroenterologia, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. avras@bol.com.br

Sao Paulo Medical Journal = Revista Paulista De Medicina
|December 2, 2010
PubMed
Summary

Kikuchi-Fujimoto disease (KFD) is a rare, benign condition causing swollen lymph nodes, often in young women. This report highlights three non-Asian cases, emphasizing KFD in differential diagnoses.

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Area of Science:

  • Immunology
  • Pathology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder typically presenting as unilateral cervical lymphadenopathy and fever.
  • While more prevalent in Asian populations, KFD requires consideration in differential diagnoses for conditions mimicking viral infections, tuberculosis, or lymphoma.
  • KFD predominantly affects young women and is diagnosed via excisional lymph node biopsy, with no specific treatment available.

Observation:

  • This case series details three non-Asian female patients diagnosed with KFD between 2003 and 2006.
  • The patients presented with characteristic cervical masses and fever, prompting further investigation.

Findings:

  • Histopathological examination confirmed Kikuchi-Fujimoto disease in all three patients.
  • The cases underscore the occurrence of KFD in non-Asian demographics, challenging its perceived geographic prevalence.
  • The diagnostic process involved excluding other lymphoproliferative and infectious conditions.

Implications:

  • Increased physician awareness of KFD in non-Asian populations is crucial for timely diagnosis and appropriate management.
  • Recognizing KFD aids in avoiding unnecessary treatments for conditions with similar presentations.
  • Further research into the etiology and geographic distribution of KFD may be warranted.