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The clinical development of mupirocin
1Beecham Laboratories, Bristol, TN 37620.
Journal of the American Academy of Dermatology
|May 1, 1990
Summary
Mupirocin, a novel topical antibiotic, effectively treats impetigo. Clinical trials confirm its safety and efficacy against common gram-positive bacteria with no detectable systemic absorption.
Area of Science:
- Microbiology
- Dermatology
- Pharmacology
Background:
- Mupirocin is a unique antibiotic structurally and mechanistically distinct from existing classes.
- It exhibits potent activity against aerobic gram-positive cocci, including Staphylococcus aureus and Streptococcus pyogenes.
Purpose of the Study:
- To evaluate the safety and efficacy of mupirocin (Bactroban ointment) for treating impetigo.
Main Methods:
- Conducted randomized, multicenter, double-blind, vehicle-controlled clinical trials.
- Assessed topical administration of 2% mupirocin in polyethylene glycol ointment.
Main Results:
- Mupirocin demonstrated significant safety and effectiveness in impetigo treatment.
- No systemic absorption of mupirocin or its metabolite (monic acid) was detected.
Conclusions:
- Topical mupirocin is a safe and effective therapeutic option for impetigo.
- Its favorable safety profile is supported by the lack of systemic absorption.