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Relationship between type 1 diabetes and atopic diseases in a twin population

S F Thomsen1, D L Duffy, K O Kyvik

  • 1Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark. sft@city.dk

Allergy
|December 3, 2010
PubMed
Abstract

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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