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Related Experiment Video

Updated: Jun 6, 2026

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

Cyprinid herpesvirus 3.

Benjamin Michel¹, Guillaume Fournier, Francois Lieffrig

¹University of Liège, Liège, Belgium.

Emerging Infectious Diseases

|December 3, 2010

Summary

Cyprinid herpesvirus 3 (CyHV-3) causes fatal disease in carp, leading to significant economic losses. This virus is also a valuable model for studying large DNA viruses and host-pathogen interactions.

Area of Science:

Virology
Aquaculture
Genomics

Background:

Cyprinid herpesvirus 3 (CyHV-3) is an emerging viral pathogen responsible for severe mortality in common and koi carp.
The virus has caused substantial economic damage to global carp aquaculture industries since its emergence in the late 1990s.
CyHV-3 presents unique characteristics, including the largest genome within the order Herpesvirales, making it a significant subject of study.

Purpose of the Study:

To investigate the fundamental and applied research potential of CyHV-3.
To explore CyHV-3 as a model for mutagenesis of large DNA viruses.
To understand the role of host temperature in regulating CyHV-3 infection outcomes.

Main Methods:

Genomic analysis of CyHV-3.

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Investigation of viral entry mechanisms, particularly through teleost fish skin.

Experimental studies on the effect of temperature on viral replication and infection dynamics.

Main Results:

CyHV-3 possesses the largest known genome among viruses in the order Herpesvirales.
Teleost fish skin is identified as a potential portal of entry for certain viral agents.
Experimental evidence indicates that host body temperature influences CyHV-3 replication, affecting infection outcomes.

Conclusions:

CyHV-3 is a significant pathogen in carp aquaculture with considerable economic impact.
The virus serves as a valuable model for fundamental research in virology, particularly for large DNA virus mutagenesis.
Host temperature plays a critical role in modulating CyHV-3 infection, offering insights into host-pathogen interactions in poikilotherms.