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Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions,

Matthieu Allez1, Konstantinos Karmiris, Edouard Louis

  • 1Department of Gastroenterology, Hôpital Saint-Louis, APHP, Université Paris 7 Denis Diderot, France; Equipe Avenir INSERM U940, France. matthieu.allez@sls.aphp.fr

Journal of Crohn'S & Colitis
|December 3, 2010
PubMed

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.

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