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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
The pattern and outcome of acute severe colitis
Lotte C Dinesen1, Alissa J Walsh, Marijana Nedeljkovic Protic
1Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
Journal of Crohn'S & Colitis
|December 3, 2010
Summary
A quarter of ulcerative colitis patients experience severe episodes, with colectomy rates increasing after multiple admissions. Disease severity on admission significantly impacts the likelihood of colectomy, highlighting the importance of early intervention.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Inflammatory Bowel Disease Research
Background:
- Limited data exists on the prevalence and long-term outcomes of acute severe ulcerative colitis (ASC).
- Prognosis of ASC is crucial for guiding therapeutic decisions in ulcerative colitis (UC) management.
Purpose of the Study:
- To determine the prevalence of ASC using Truelove and Witts' (TW) criteria.
- To assess the relationship between disease activity, recurrence likelihood, and long-term prognosis in ASC patients.
Main Methods:
- A systematic review was conducted on UC patients diagnosed in Oxford.
- Prevalence of ASC and colectomy rates were analyzed based on disease severity and admission history.
Main Results:
- 24.8% of UC patients experienced at least one ASC admission.
- Colectomy rates were significantly higher in patients with ASC (39.8%) compared to those without (3.4%).
- Colectomy risk increased with disease severity on admission and after multiple ASC episodes.
Conclusions:
- Approximately 25% of UC patients have at least one ASC episode.
- Colectomy rates are 20% after the first ASC admission and 40% after the second.
- The biological severity of ASC on admission is a key predictor of colectomy likelihood.
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