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Long-term efficacy of nitroglycerin patch in stable angina pectoris
R Greco1, M Schiattarella, S Wolff
1Division of Cardiology, Ospedale Monaldi, Naples, Italy.
The American Journal of Cardiology
|June 4, 1990
Summary
This study found that a 10 mg nitroglycerin (NTG) patch significantly reduced angina attacks and nitroglycerin consumption in patients with stable angina pectoris. Exercise tolerance also improved during both short-term and long-term treatment.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Stable angina pectoris is a common cardiovascular condition.
- Nitroglycerin (NTG) is a widely used vasodilator for angina treatment.
Purpose of the Study:
- To evaluate the subchronic and chronic efficacy of a 10 mg nitroglycerin (NTG) patch in patients with stable angina pectoris.
Main Methods:
- A 2-month double-blind, placebo-controlled crossover study followed by an open-label treatment period.
- Efficacy assessed via anginal attack frequency, NTG consumption, and multistage treadmill exercise testing.
- 27 patients completed the study, with data analyzed using multivariate analysis.
Main Results:
- Significant reduction in daily angina attacks and NTG consumption compared to placebo (p < 0.001).
- Improved exercise duration, time to angina onset, and time to ST-segment depression during subchronic treatment.
- Sustained improvements observed throughout the chronic treatment phase.
Conclusions:
- The 10 mg nitroglycerin patch demonstrates significant efficacy in managing stable angina pectoris.
- Both subchronic and chronic administration of the NTG patch provide clinical benefits and improve exercise capacity.