Related Experiment Video
Updated: Jun 6, 2026

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
Published on: July 12, 2019
[Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration]
Akinobu Suzuki1, Takuya Uemura, Hiroaki Nakamura
1Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Japan.
Abstract:
In the clinic, it is a well-accepted fact that traumatic brain injury or peripheral nerve disorders affect healing of bone fractures. Recent studies have focused on the neurogenic control of bone metabolism, and the understanding of neural involvement in fracture healing and bone regeneration is increasing. In fracture healing and new bone formation, nerve fibers rapidly regenerate and increase in numbers in new bone, but decrease again during the remodeling phase. Previous studies have shown that denervation negatively affects fracture-healing. Neurotransmitters, including neuropeptides and catecholamine, are thought to play a key role in bone regeneration.
Related Concept Videos
Bone Remodeling and Repair
Bone Remodeling
Neurogenesis and Regeneration of Nervous Tissue
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Osteoclasts in Bone Remodeling
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

