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04:38
A Murine Tail Lymphedema Model
Published on: February 10, 2021
A tale of tailless
Hongxing Gui1, Mei-Ling Li, Chih-Cheng Tsai
1Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, N.J., USA. gui@biology.rutgers.edu
Developmental Neuroscience
|December 3, 2010
Summary
Tailless (Tll) and Tlx are nuclear receptors crucial for neural stem cell (NSC) self-renewal in flies and mice. They function as transcriptional repressors, maintaining NSC populations in developing and adult animals.
Area of Science:
- Developmental Biology
- Molecular Biology
- Neuroscience
Background:
- Tailless (Tll) and Tlx are conserved orphan nuclear receptors.
- They are specifically expressed in the eye and forebrain.
- Tll and Tlx function as transcriptional repressors.
Purpose of the Study:
- To review current knowledge on Tll and Tlx.
- To elucidate their role in neural stem cell (NSC) self-renewal.
- To describe their transcriptional network in maintaining NSCs.
Main Methods:
- Literature review of studies on Tll and Tlx.
- Analysis of their interactions with corepressors and chromatin modifiers.
- Examination of their expression patterns and functional importance in NSCs.
Main Results:
- Tll and Tlx interact with Atrophin proteins, lysine-specific histone demethylase 1, and histone deacetylases.
- These receptors are expressed in neural stem cells (NSCs) in both Drosophila and mice.
- Tll and Tlx are essential for NSC self-renewal.
Conclusions:
- Tll and Tlx play a critical role in maintaining neural stem cell populations.
- Their transcriptional network is vital for NSC self-renewal in both developing and adult animals.
- Understanding Tll and Tlx function provides insights into neural stem cell biology.
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