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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Optimizing chemotherapy: concomitant medication lists.

M H Hanigan1, B L Dela Cruz, S S Shord

  • 1Department of Cell Biology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. marie-hanigan@ouhsc.edu

Clinical Pharmacology and Therapeutics
|December 3, 2010
PubMed
Summary
This summary is machine-generated.

Accurate recording of all medications, including over-the-counter drugs and remedies, is crucial for cancer chemotherapy patients. Medical records frequently miss many concomitant drugs, potentially impacting treatment effectiveness and safety.

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Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Pharmacy

Background:

  • Chemotherapy response variability is influenced by concomitant medications.
  • Accurate patient medication history is essential for safe and effective cancer treatment.
  • Existing methods for documenting patient drug intake are often incomplete.

Purpose of the Study:

  • To assess the accuracy of concomitant medication lists in cancer patient medical records.
  • To quantify the discrepancies between documented and actual patient drug use.
  • To highlight the implications for drug interactions and treatment outcomes.

Main Methods:

  • Validated medication lists were compiled using questionnaires, patient interviews, and medical chart reviews.
  • Data collection focused on prescription drugs, nonprescription drugs, and other remedies taken within three days of chemotherapy.
  • Comparison of documented medications against patient-reported and interviewed information.

Main Results:

  • Patients used an average of 4.8 prescription drugs, 1.6 nonprescription drugs, and 1.6 other remedies.
  • Medical records failed to report 24% of prescription drugs, 84% of nonprescription drugs, and 83% of other remedies.
  • Electronic medical records showed improvement but still omitted over 75% of nonprescription drugs and other remedies.

Conclusions:

  • Significant deficiencies exist in documenting concomitant medications for cancer patients.
  • Incomplete medication records pose a risk for unmanaged drug interactions and altered chemotherapy pharmacokinetics.
  • Improved methods for capturing comprehensive patient medication histories are urgently needed.