Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Blood-brain Barrier

The Blood-brain Barrier

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lactate dehydrogenase A inhibition-induced metabolic reprogramming combined with targeted ceria nanozymes protects against myocardial ischemia-reperfusion injury.

Biomaterials advances·2026

Same author

Personalised thrombo-embolic risk prediction after endometrial cancer surgery: an explainable AI approach using SHAP.

NPJ digital medicine·2026

Same author

Management and outcome of adult generalized tetanus patients in a tertiary hospital in Anhui, China: a retrospective study.

Frontiers in public health·2026

Same author

Case Report: A Case of Neuroendocrine Carcinoma of the Endometrium with Deficient DNA Mismatch Repair Had Achieved Clinical Complete Response after Combination Therapy.

Oncology research·2026

Same author

From haploid inducer to CMS donor: repurposing of CENH3 to create a CMS line in a single step in Brassica napus.

Plant cell reports·2026

Same author

Bellidifolin mitigates doxorubicin-induced myocardial injury via regulating oxidative stress, inflammation, and apoptosis: a combination of network pharmacology and experiments.

Journal of molecular histology·2026

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

Functional identification of neuroprotective molecules.

Cheng Dai¹, Dong Liang, Huiwu Li

¹Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

|December 3, 2010

Summary

The brain can protect itself from damage through a process called preconditioning. Researchers identified 28 new genes that help protect neurons from injury, offering hope for treating neurological diseases.

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Related Experiment Videos

Last Updated: Jun 6, 2026

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Real-Time Impedance-based Cell Analyzer as a Tool to Delineate Molecular Pathways Involved in Neurotoxicity and Neuroprotection in a Neuronal Cell Line

Published on: August 9, 2014

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

The central nervous system exhibits neuroprotection following sub-lethal stress, a phenomenon known as preconditioning.
Understanding the genetic basis of this survival response is crucial for developing therapeutic strategies.

Purpose of the Study:

To identify and characterize genes involved in neuroprotection using a functional cloning strategy.
To investigate the brain's repertoire of neuroprotective genes and their potential therapeutic applications.

Main Methods:

A functional cloning strategy was employed to screen for neuroprotective genes.
Primary rat cortical neurons were used to test gene protection against oxygen-glucose deprivation (OGD) and N-methyl-D-aspartate (NMDA) excitotoxicity.

Main Results:

31 putative neuroprotective genes were identified.
28 of these genes were confirmed to provide significant protection against OGD and NMDA-induced neuronal injury.
This highlights a diverse genetic toolkit for neuroprotection within the brain.

Conclusions:

The brain possesses a broad and varied set of genes capable of conferring neuroprotection.
Further research into these identified genes could lead to novel treatments for neurological injuries, including those from ischemia and neurodegenerative diseases.