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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
Published on: February 22, 2016
The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse
Helen Waller-Evans1, Simone Prömel, Tobias Langenhan
1Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom.
Plos One
|December 3, 2010
Summary
The G protein-coupled receptor 126 (GPR126) is crucial for embryonic development and cardiovascular formation in mice. This study reveals GPR126
Area of Science:
- Molecular Biology
- Developmental Biology
- Genetics
Background:
- Adhesion-GPCRs mediate vital cell interactions and are linked to human diseases.
- GPR126, an orphan Adhesion-GPCR, is implicated in zebrafish myelination and human height variation.
- The mammalian function of GPR126 remains largely unknown.
Purpose of the Study:
- To investigate the physiological role of GPR126 in mammals.
- To characterize the function of GPR126 during embryonic development.
Main Methods:
- Targeted mutation of the GPR126 gene in mice.
- Analysis of GPR126 knockout mouse phenotype.
Main Results:
- GPR126 is essential for embryonic viability in mice.
- GPR126 plays a critical role in cardiovascular development.
- GPR126 deficiency leads to embryonic lethality.
Conclusions:
- GPR126 is indispensable for mammalian embryonic development.
- GPR126 is vital for cardiovascular system formation.
- Further research into GPR126 functions is warranted.
