Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The therapeutic potential of N-acetylcysteine across multiple organ systems: a narrative review.

La Clinica terapeutica·2026
Same author

Experimental evidence of life history trade-offs during ultra-endurance physical activity.

Evolutionary human sciences·2026
Same author

Role of GIRK2 channels in morphine-induced metabolite changes in the rostral ventromedial medulla.

Magnetic resonance imaging·2026
Same author

Epigenetic Drivers of Pulmonary Hypertension: Environment Meets Genome.

Cureus·2026
Same author

A narrative review on artificial intelligence in neurosurgery: ethical challenges and implementation considerations.

Annals of medicine and surgery (2012)·2025
Same author

Identifying independent predictors of malignancy in indeterminate thyroid nodules: a systematic review.

Annals of medicine and surgery (2012)·2025
Same journal

Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.

Current hypertension reports·2026
Same journal

Correction to: Should Incretin Agonist-Based Drugs be Considered for First Line Antihypertensive Therapy?

Current hypertension reports·2026
Same journal

Intersection of Pediatric Hypertension and Cardiovascular-Kidney-Metabolic Disease.

Current hypertension reports·2026
Same journal

Combined Aldosterone Synthase and SGLT2 Inhibition: A Recipe for Success in CKD with Uncontrolled Blood Pressure?

Current hypertension reports·2026
Same journal

Leveraging the Electronic Health Record to Identify and Manage Resistant Hypertension.

Current hypertension reports·2026
Same journal

Should Incretin Agonist-Based Brugs be Considered for First Line Antihypertensive Therapy?

Current hypertension reports·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

Epigenetics and hypertension.

Richard M Millis1

  • 1Department of Physiology & Biophysics, Howard University College of Medicine, 520 "W" Street NW, Washington, DC 20059, USA. rmillis@howard.edu

Current Hypertension Reports
|December 3, 2010
PubMed
Summary
This summary is machine-generated.

Epigenetics, involving DNA methylation and histone modifications, influences hypertension risk through environmental gene interactions. These epigenetic mechanisms impact kidney development, stress responses, and blood vessel function, offering potential therapeutic targets.

More Related Videos

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
08:08

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

Published on: June 10, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta
08:08

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

Published on: June 10, 2015

Area of Science:

  • Epigenetics and Molecular Biology
  • Cardiovascular Physiology
  • Developmental Biology

Background:

  • Epigenetics describes environment-gene interactions, primarily DNA methylation and histone modification, without altering DNA sequence.
  • Hypertension is a complex condition influenced by genetic and environmental factors, with emerging evidence for epigenetic involvement.

Purpose of the Study:

  • To review evidence linking epigenetic mechanisms to the development and progression of hypertension.
  • To highlight specific epigenetic pathways and genes implicated in various hypertensive states.

Main Methods:

  • Review of existing literature on epigenetics and hypertension.
  • Analysis of studies examining DNA methylation, histone acetylation, and gene expression in hypertension models and human conditions.
  • Focus on key genes and pathways such as renin-angiotensin system, connective-tissue growth factor, and steroid metabolism.

Main Results:

  • DNA methylation and histone acetylation can impair nephron development, exacerbating salt-sensitive hypertension.
  • Maternal nutritional deficiencies impact offspring's renin-angiotensin system gene expression.
  • Placental gene methylation patterns may serve as preeclampsia biomarkers.
  • Epigenetic modifications are linked to stress responses, autonomic function, and vascular remodeling in hypertension.
  • Specific epigenetic factors like Dot1a influence genes controlling vascular compliance and cortisol metabolism.

Conclusions:

  • Epigenetic mechanisms play a significant role in diverse hypertensive conditions, including essential hypertension.
  • Understanding these environment-gene interactions provides novel targets for hypertension management.
  • Further research into epigenetic modifications could lead to innovative therapeutic strategies for blood pressure regulation.