Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver.

Journal of hepatology·2023
Same author

The effect of prophylactic hemoclip placement and risk factors of delayed post-polypectomy bleeding in polyps sized 6 to 20 millimeters: a propensity score matching analysis.

BMC gastroenterology·2020
Same author

The cellular origins of cancer with particular reference to the gastrointestinal tract.

International journal of experimental pathology·2020
Same author

Aldolase triggers metabolic reprogramming in colorectal cancer in hypoxia and stiff desmoplastic microenvironments.

Colloids and surfaces. B, Biointerfaces·2020
Same author

Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas.

EBioMedicine·2019
Same author

Periportal SRY (Sex Determining Region Y)-Box 9-Positive Hepatocytes: Progenitors With a Biliary Leaning.

Hepatology (Baltimore, Md.)·2019
Same journal

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology·2026
Same journal

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

The Journal of pathology·2026
Same journal

Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.

The Journal of pathology·2026
Same journal

FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma.

The Journal of pathology·2026
Same journal

Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

The Journal of pathology·2026
Same journal

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

The Journal of pathology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Cancer stem cells: problems for therapy?

Malcolm R Alison1, Susan M L Lim, Linda J Nicholson

  • 1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. m.alison@qmul.ac.uk

The Journal of Pathology
|December 3, 2010
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and metastasis. Targeting CSCs, including their self-renewal pathways and epithelial-mesenchymal transition (EMT), is crucial for effective cancer therapies.

More Related Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Tumors contain cancer stem cells (CSCs) responsible for tumor growth and expansion.
  • Epithelial-mesenchymal transition (EMT) generates CSCs with invasive and metastatic potential.
  • Cancer progression involves evolutionary processes, complicating eradication of all stem cell types.

Purpose of the Study:

  • To review the attributes of CSCs and their identification across various cancers.
  • To discuss the origin of cancer from normal stem cells.
  • To explore therapeutic strategies targeting CSCs.

Main Methods:

  • Prospective isolation of CSCs using surface markers or enzyme activity.
  • Assessment via sphere-forming assays and xenotransplantation into immunocompromised mice (tumor-propagating cells, TPCs).
  • Review of studies identifying CSCs in diverse cancer types.

Main Results:

  • CSCs are a sub-population within tumors capable of self-renewal and expansion.
  • EMT contributes to CSC generation, enhancing invasiveness and metastasis.
  • Evidence suggests cancer can arise from normal stem cells or their descendants.

Conclusions:

  • Understanding CSCs is vital for developing effective cancer therapies.
  • Targeting CSC self-renewal pathways (Wnt, Notch, Hedgehog), aldehyde dehydrogenase activity, EMT, miRNAs, and epigenetic modifiers offers therapeutic potential.
  • A single-target approach may be insufficient due to cancer's evolutionary nature.