Related Experiment Video
Updated: Jun 6, 2026

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
Published on: September 29, 2023
Eutypoids B-E produced by a Penicillium sp. strain from the North Sea
Dirk Schulz1, Birgit Ohlendorf, Heidi Zinecker
1Kieler Wirkstoff-Zentrum at the Leibniz-Institute of Marine Sciences (IFM-GEOMAR), Am Kiel-Kanal 44, 24106 Kiel, Germany.
Abstract:
Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β.
Related Concept Videos
Production of Antibiotics
Diversity of Protists I
Bacterial Phylum Spirochaetes
Deep Sea Microbial Ecology
Bacterial Phylum Planctomycetes
Bacterial Phylum Tenericutes

