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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Association between placental mineral deposition, villous architecture and fetal aneuploidy

R Khan1, M Sanders, L Ernst

  • 1Department of Obstetrics and Gynaecology, South Mead Hospital, Bristol, UK. rahila.khan1@ntlworld.com

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|December 4, 2010
PubMed

We retrospectively evaluated the relationship between fetal aneuploidy and placental mineral deposits and villous architecture in 2nd trimester placentas of mid-trimester pregnancy terminations for fetal anomaly. Study cases were aneuploid and matched with euploid controls. Six slides per case were histologically evaluated. Our findings showed significantly increased subtrophoblastic mineral depositions in aneuploidy placentas; also, villous architecture changes between study and control cases were significant for multifocal/extensive villous scalloping and syncytial budding. Our conclusion was that placental histological findings of extensive subtrophoblastic mineral deposition, multifocal/extensive villous scalloping and syncytial budding may suggest aneuploidy.

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