Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Root-Locus Method01:19

Root-Locus Method

A cruise control system in a car is designed to maintain a specified speed automatically by adjusting the gas pedal. The system continuously measures the vehicle's speed and makes fine adjustments to the pedal to achieve this goal. The root locus method is particularly useful for understanding how the cruise control system's behavior changes under varying conditions, such as when the car goes uphill, downhill, or faces strong wind resistance.
This system can be represented by a block diagram,...
Properties of the Root Locus01:05

Properties of the Root Locus

The root locus method is an invaluable tool for analyzing higher-order systems without needing to factor the denominator of the transfer function. A pole of the system is identified when the characteristic polynomial in the transfer function's denominator equals zero.
To determine if a point lies on the root locus, the criterion involves the sum of angles contributed by all poles and zeros to that point. Specifically, this sum must be an odd multiple of 180 degrees. The gain at any point on the...
Plotting and Calibrating the Root Locus01:19

Plotting and Calibrating the Root Locus

Root loci often diverge as system poles shift from the real axis to the complex plane. Key points in this transition are the breakaway and break-in points, indicating where the root locus leaves and reenters the real axis. The branches of the root locus form an angle of 180/n degrees with the real axis, where n is the number of branches at a breakaway or break-in point.
The maximum gain occurs at the breakaway points between open-loop poles on the real axis, while the minimum gain is observed...
Locus of Control01:26

Locus of Control

Locus of control describes how individuals perceive the causes of events in their lives, influencing motivation and well-being. Introduced by Julian Rotter in 1954, it is categorized into internal and external locus of control.Internal Locus of ControlIndividuals with an internal locus of control believe their actions determine outcomes, fostering responsibility, self-efficacy, and motivation. For example, an employee may attribute career success to hard work. Research links this mindset to...
Construction of Root Locus01:15

Construction of Root Locus

The construction of a root locus involves several key steps to analyze and visualize the behavior of a system's poles with varying gain. The number of branches in the root locus equals the number of closed-loop poles and is symmetrical about the real axis.
For positive gain values, the root locus exists on the real axis to the left of an odd number of finite open-loop poles or zeros. The root locus starts at the open-loop poles and traces the paths of the closed-loop poles as the gain increases.
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repeat expansions in Parkinson's disease and parkinsonism across ancestries: insights from a global genetic cohort.

medRxiv : the preprint server for health sciences·2026
Same author

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same author

Haplotype-resolved DNA methylation at the <i>APOE</i> locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.

NPJ dementia·2026
Same author

A new AI assisted approach aligns data standards and accelerates interoperability in biomedical research.

NPJ digital medicine·2026
Same author

Pathology and Genetics in a Global Cohort of Parkinsonian Disorders.

JAMA neurology·2026
Same author

PD GENEration: An International Parkinson's Disease Genetic Research Study.

medRxiv : the preprint server for health sciences·2026
Same journal

Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer's disease progression in the AppNL-G-F mouse.

Brain : a journal of neurology·2026
Same journal

Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same journal

Lower motor neuron disorders: time for a closer look.

Brain : a journal of neurology·2026
Same journal

Reply: Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same journal

Propionic acid and neurofilament light chain in multiple sclerosis.

Brain : a journal of neurology·2026
Same journal

Propionic acid in multiple sclerosis: a phase 2b, double-blind, randomized placebo-controlled trial.

Brain : a journal of neurology·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Another locus, a new method

Andrew B Singleton1, J Raphael Gibbs

  • 1NIH-Molecuar Genetics Section, Bldg 35, Rm 1A1000, 35 Lincoln Drive, Bethesda, MD 20892, USA. singleta@mail.nih.gov

Brain : a Journal of Neurology
|December 4, 2010
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Single-Copy Gene Locus Chromatin Purification in Saccharomyces cerevisiae
10:33

Single-Copy Gene Locus Chromatin Purification in Saccharomyces cerevisiae

Published on: November 17, 2023

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Related Experiment Videos

Last Updated: Jun 6, 2026

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Single-Copy Gene Locus Chromatin Purification in Saccharomyces cerevisiae
10:33

Single-Copy Gene Locus Chromatin Purification in Saccharomyces cerevisiae

Published on: November 17, 2023

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013