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Pseudoexfoliation as a risk factor for peripheral vascular disease: a case-control study
M R Praveen1, S K Shah, A R Vasavada
1Iladevi Cataract & IOL Research Center, Raghudeep Eye Clinic, Ahmedabad, India.
Eye (London, England)
|December 4, 2010
Summary
Pseudoexfoliation (PEX) is linked to peripheral vascular disease (PVD) in cataract patients. Individuals with PEX and cataracts showed significantly lower ankle-brachial index (ABI) values, indicating a higher PVD risk.
Area of Science:
- Ophthalmology
- Vascular Medicine
- Geriatrics
Background:
- Pseudoexfoliation (PEX) is an age-related condition that can affect the eye.
- Peripheral vascular disease (PVD) is a circulatory condition that affects blood vessels outside the brain and heart.
- Age-related cataract is a common cause of vision loss in older adults.
Purpose of the Study:
- To investigate the association between pseudoexfoliation (PEX) and peripheral vascular disease (PVD) in patients with age-related cataract.
- To determine if PEX is a risk factor for PVD in this population.
Main Methods:
- An observational, age-matched case-control study was conducted with 160 patients over 60 years old.
- Forty patients with PEX and cataracts (cases) were compared to 120 patients with cataracts but without PEX (controls).
- Ankle-brachial index (ABI) was measured using color Doppler imaging to assess PVD risk, with ABI < 0.90 considered abnormal.
Main Results:
- Patients with PEX (cases) had a significantly lower mean ABI (0.88 ± 0.02) compared to controls (0.98 ± 0.03; P < 0.001).
- This lower ABI in PEX cases persisted regardless of systemic illnesses like hypertension or diabetes.
- Multiple regression analysis indicated that PEX increased the odds of having a low ABI by 150 times (P < 0.001).
Conclusions:
- Pseudoexfoliation (PEX) is significantly associated with a lower ankle-brachial index (ABI) in patients with age-related cataract.
- PEX may serve as an independent risk factor for peripheral vascular disease (PVD).
- Further research is warranted to explore the underlying mechanisms linking PEX and PVD.
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