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Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Prognostic value of changes in arterial stiffness in men with coronary artery disease

Iana A Orlova1, Eradzh Yu Nuraliev, Elena B Yarovaya

  • 1Outpatient Department, Russian Cardiology Research Center, Moscow, Russian Federation. orlova@cardio.ru

Vascular Health and Risk Management
|December 4, 2010
PubMed

Insights

Improved arterial stiffness in men with coronary artery disease (CAD) predicts a better prognosis. Reduced brachial-ankle pulse wave velocity (PWVba) after six months of therapy indicates fewer major adverse cardiac events (MACE).

Area of Science:

  • Cardiovascular Medicine
  • Vascular Physiology
  • Clinical Cardiology

Background:

  • Men with coronary artery disease (CAD) exhibit increased arterial stiffness.
  • The prognostic significance of changes in arterial function over time with treatment is not well understood.

Purpose of the Study:

  • To determine if improved large artery rigidity predicts a better prognosis in men with CAD.
  • To assess the prognostic value of changes in arterial stiffness following conventional therapy.

Main Methods:

  • 161 men with CAD underwent brachial-ankle pulse wave velocity (PWVba) measurements at baseline and after six months.
  • Follow-up was 3.5 years, with endpoints including major adverse cardiac events (MACE).
  • Patients were categorized into groups based on PWVba improvement (ΔPWVba < 0%) or lack thereof (ΔPWVba ≥ 0%).

Main Results:

  • After six months, 47.2% of men showed improved PWVba, while 52.8% did not.
  • The group with improved PWVba experienced significantly fewer MACE (6 events) compared to the group without improvement (24 events) (P < 0.001).
  • Absence of PWVba decrease independently predicted MACE (RR 3.99), with 80% sensitivity and 54% specificity.

Conclusions:

  • Conventional therapy can lead to improvements in arterial stiffness within six months.
  • An improvement in arterial stiffness identifies patients with a more favorable prognosis in CAD.
  • Monitoring PWVba changes offers a valuable tool for risk stratification in men with CAD.
Abstract

Keywords:
arterial stiffnesscoronary artery diseaseprognosis

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