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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Updated: Jun 6, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Cullins and cancer.

Jennifer Lee1, Pengbo Zhou

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Genes & Cancer
|December 4, 2010
PubMed
Summary
This summary is machine-generated.

Cullin-RING E3 complexes (CRLs) regulate cell processes; their dysregulation drives cancer by affecting oncoproteins and tumor suppressors. This review explores CRLs, their substrates, regulation, and roles in carcinogenesis.

Keywords:
cancercullinubiquitin

Related Experiment Videos

Last Updated: Jun 6, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • Cullin-RING complexes (CRLs) are E3 ubiquitin ligases crucial for cellular processes.
  • Substrate specificity is determined by cullin receptors, controlling degradation.
  • Dysregulated CRL activity is implicated in oncogenesis.

Purpose of the Study:

  • To review cullin complexes, their substrates, and regulatory pathways.
  • To elucidate the mechanisms of cullin involvement in carcinogenesis.
  • To discuss CRLs' dual role in facilitating or inhibiting cancer development.

Main Methods:

  • Literature review of cullin-RING E3 ligase complexes.
  • Analysis of substrate specificity and receptor interactions.
  • Examination of regulatory mechanisms impacting CRL activity.

Main Results:

  • CRLs assemble diverse E3 complexes through various substrate receptors.
  • Cullin-mediated degradation impacts proliferation, differentiation, and apoptosis.
  • Aberrant CRL activity leads to oncoprotein accumulation or tumor suppressor loss.

Conclusions:

  • CRLs are critical regulators of cellular homeostasis.
  • Understanding CRLs and their substrates is key to cancer research.
  • Targeting CRLs may offer therapeutic strategies for oncogenesis.