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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

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Metal-Assisted and Microwave-Accelerated Evaporative Crystallization.

Melissa A Pinard¹, Kadir Aslan

¹Morgan State University, Department of Chemistry, Baltimore, Maryland 21251, United States.

Crystal Growth & Design

|December 4, 2010

Summary

Metal-assisted and microwave-assisted evaporative crystallization (MA-MAEC) rapidly crystallizes small molecules. This novel technique grows larger crystals and allows on-demand polymorph selection, significantly faster than traditional methods.

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Area of Science:

Materials Science
Chemical Engineering
Crystallization Science

Background:

Evaporative crystallization is a standard technique for small molecule crystallization.
Controlling polymorphs and crystal size remains challenging with conventional methods.
Rapid, selective crystallization is crucial for pharmaceutical and materials development.

Purpose of the Study:

To introduce a novel platform technology, metal-assisted and microwave-assisted evaporative crystallization (MA-MAEC).
To demonstrate the rapid and selective crystallization of small molecules using MA-MAEC.
To investigate the effect of MA-MAEC on crystal size and polymorph control.

Main Methods:

Utilized silver nanoparticles and microwave heating for evaporative crystallization.
Employed a model small molecule (glycine) for crystallization experiments.
Compared crystal growth on silver nanostructures versus blank glass slides, with and without microwave irradiation.

Main Results:

Achieved crystallization of glycine in seconds using the MA-MAEC technique.
Observed larger glycine crystal formation on silver nanostructures compared to glass slides.
Demonstrated potential for selective polymorph growth on-demand.

Conclusions:

MA-MAEC is a highly efficient technique for rapid small molecule crystallization.
The method offers enhanced control over crystal size and polymorph selection.
MA-MAEC presents a significant advancement over conventional evaporative crystallization methods.