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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 6, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Incompletely excised basal cell carcinomas: Our guidelines.

P Longhi1, M Paola Serra, E Robotti

  • 1Department of Plastic and Reconstructive Surgery "Ospedali Riuniti di Bergamo", Bergamo, Italy.

Oncotargets and Therapy
|December 4, 2010
PubMed
Summary
This summary is machine-generated.

Early re-excision for basal cell carcinoma (BCC) with margin involvement is crucial. A "wait and see" approach led to significant recurrence rates, especially after five years, highlighting the need for prompt surgical intervention.

Keywords:
basal cell carcinomaexciseguidelinestumor

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Last Updated: Jun 6, 2026

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Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Basal cell carcinoma (BCC) is a common skin cancer.
  • Incomplete excision leading to margin involvement presents a management challenge.
  • Previous studies have explored re-excision versus observation for involved margins.

Purpose of the Study:

  • To compare outcomes of re-excision versus a "wait and see" approach for BCC with margin involvement.
  • To evaluate recurrence rates in patients with incompletely excised BCC.
  • To identify factors influencing patient follow-up and treatment decisions.

Main Methods:

  • Retrospective review of 982 patients treated for BCC between 1996 and 2004.
  • Identification and comparison of two cohorts: BCC with re-excision and BCC with "wait and see" management.
  • Analysis of recurrence rates and follow-up adherence.

Main Results:

  • 16 out of 982 patients presented with margin involvement.
  • In the "wait and see" group (80 patients), 39 were followed up, and 16 experienced recurrences over 8 years, with many occurring after 5 years.
  • High detection rates of residual tumors in re-excised patients and difficulties in follow-up for the "wait and see" group were noted.

Conclusions:

  • Early re-excision is recommended for BCC with any margin involvement (focal, lateral, or deep) to minimize recurrence risk.
  • The "wait and see" approach is associated with a significant risk of recurrence and challenges in patient follow-up.
  • Clinical follow-up is reserved for patients with poor general health precluding re-operation.