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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Synthesis of difluoroaryldioxoles using BrF3

Youlia Hagooly1, Michael J Welch, Shlomo Rozen

  • 1School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.

Organic & Biomolecular Chemistry
|December 4, 2010
PubMed
Summary

A new method synthesizes difluoroaryldioxoles from catechols using thiophosgene and bromine trifluoride. This efficient process yields potentially biologically active compounds in moderate to high amounts.

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