Effect of thyrotropin-releasing hormone (TRH) on motor performance of hemiparetic stroke patients

The maximum walking speed, the stability of standing balance, and isokinetic strength for knee extension on the both sides were examined in 7 hemiparetic stroke patients before and 10-20 min after intravenous administration of 2-mg TRH. The maximum walking speed, the stability of standing balance and the strength of the affected side increased significantly with TRH but the strength of the non-affected side did not change. It seems that TRH enables functionally depressed areas to resume activity.