Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 6, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

A novel sheep vertebral bone defect model for injectable bioactive vertebral augmentation materials.

X S Zhu1, Z M Zhang, H Q Mao

  • 1Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Journal of Materials Science. Materials in Medicine
|December 4, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test of CP Symmetry in the Neutral Decays of Λ via J/ψ→ΛΛ[over ¯].

Physical review letters·2026
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

Precise Measurement of Matter-Antimatter Asymmetry with Entangled Hyperon-Antihyperon Pairs.

Physical review letters·2026
Same author

Observation of Λ[over ¯]p→K^{+}π^{+}π^{-}π^{0} and Λ[over ¯]p→K^{+}π^{+}π^{-}2π^{0}.

Physical review letters·2026
Same author

First Measurement of the D_{s}^{+}→K^{0}μ^{+}ν_{μ} Decay.

Physical review letters·2026
Same author

Observation of the Electromagnetic Radiative Decays of the Λ(1520) and Λ(1690) to γΣ^{0}.

Physical review letters·2026

New injectable bone substitutes, like calcium phosphate cement (CPC), enhance vertebral strength and promote bone growth. A sheep model validated its use for evaluating bioactive materials in vertebral reconstruction.

Area of Science:

  • Orthopedics and Biomaterials Science
  • Surgical Innovation
  • Regenerative Medicine

Background:

  • Traditional polymethylmethacrylate lacks biological activity for bone repair.
  • Injectable, osteogenic bone substitutes are needed for vertebroplasty and kyphoplasty.
  • Evaluating new bone graft materials requires robust in vivo models.

Purpose of the Study:

  • To develop and validate a sheep vertebral bone defect model.
  • To assess the in vivo performance of a novel calcium phosphate cement (CPC).
  • To evaluate CPC's osteogenic effect, biodegradability, and impact on vertebral mechanics.

Main Methods:

  • Experimental bone voids were created in lumbar vertebrae (L2-L5) of mature sheep.
  • Defects were augmented with calcium phosphate cement (CPC) or treated with sham.

More Related Videos

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

  • Vertebrae were analyzed at 2 and 24 weeks for strength, stiffness, osseointegration, and osteogenesis.

    • Main Results:

    • Calcium phosphate cement (CPC) significantly improved vertebral strength and stiffness at 24 weeks.
    • Substantial osteogenesis was observed in CPC-augmented and sham defects.
    • The sheep vertebral defect model proved replicable for material evaluation.

    Conclusions:

    • The developed sheep model is suitable for evaluating injectable bioactive bone materials.
    • CPC demonstrates osteogenic potential and improves mechanical properties in vertebral defects.
    • Further research can utilize this model for advanced bone reconstruction strategies.