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Updated: Jun 6, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

[Viral arthritides].

E Märker-Hermann1, N Schütz, H Bauer

  • 1Klinik Innere Medizin IV (Rheumatologie, klinische Immunologie und Nephrologie), HSK Dr. Horst Schmidt Klinik GmbH, Ludwig Erhard Strasse 100, Wiesbaden, Germany. Elisabeth.Maerker-Hermann@HSK-Wiesbaden.de

Zeitschrift Fur Rheumatologie
|December 4, 2010
PubMed
Summary
This summary is machine-generated.

Viruses frequently cause acute polyarthritis globally. While often with other symptoms, isolated arthritis can mimic rheumatoid arthritis, necessitating awareness of viral causes.

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Last Updated: Jun 6, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Area of Science:

  • Virology
  • Rheumatology
  • Immunology

Context:

  • Acute polyarthritis is a global health concern.
  • Viral infections are common causes of arthritis, sometimes mimicking rheumatoid arthritis.
  • Travel to endemic regions increases exposure to arthritogenic viruses like alpha-viruses.

Purpose:

  • To review the role of viruses in causing acute polyarthritis.
  • To discuss the mechanisms by which viruses induce arthritis.
  • To highlight common arthritogenic viruses in different geographical regions.

Summary:

  • Viruses are significant etiologic agents of acute polyarthritis worldwide.
  • Common arthritogenic viruses include parvovirus B19, rubella, hepatitis B and C in Europe/North America, and alpha-viruses in other regions.
  • Viral arthritis mechanisms involve direct infection, immune complex formation, cytokine induction, and autoimmune reactions.

Impact:

  • Enhances understanding of viral arthritis pathogenesis.
  • Informs differential diagnosis for patients presenting with arthritis.
  • Raises awareness among clinicians, especially rheumatologists, regarding travel-associated viral arthritis.