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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

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Chorea associated with anti-phospholipid antibodies: case report.

J Demonty¹, M Gonce, P Ribai

¹Service des Maladies Infectieuses et de Médecine Interne Générale, Centre Hospitalier Universitaire de Liège, Liège, Belgique. jean.demonty@chu.ulg.ac.be

Acta Clinica Belgica

|December 7, 2010

Summary

This summary is machine-generated.

A rare case of chorea in a teenager was successfully treated with steroids and aspirin. This autoimmune condition, linked to antiphospholipid syndrome, showed significant improvement with targeted therapy.

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Area of Science:

Neurology
Immunology
Genetics

Background:

Chorea is a neurological movement disorder characterized by involuntary, irregular, and unpredictable movements.
Antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of blood clots and pregnancy complications.

Observation:

A 17-year-old male presented with acute-onset chorea affecting all four limbs.
Genetic testing for Fibrillin 1, familial chorea, and Huntington's disease was negative.
High levels of anti-beta2-GP1 IgG, anticardiolipin antibodies, and lupus anticoagulant were detected, indicative of APS.

Findings:

Brain imaging (EEG, MRI) revealed no structural abnormalities.
Positron Emission Tomography (PET) scan showed bilateral striatal hypermetabolism.
Treatment with methylprednisolone and low-dose aspirin led to complete resolution of choreic movements within two months.
Follow-up PET scan demonstrated a reversion of striatal hypermetabolism to a normal pattern.

Implications:

This case highlights a rare presentation of chorea secondary to antiphospholipid syndrome.
Early diagnosis and treatment with immunosuppressants and anticoagulants can lead to favorable outcomes in APS-related chorea.
The findings suggest a potential autoimmune or inflammatory mechanism underlying striatal dysfunction in APS.