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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 6, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

[mir-17-92 cluster and tumor].

Rui-Fang Yang1, Li-Juan Chen, Jian-Yong Li

  • 1Department of Hematology, The First Affiliated Hospital, Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 7, 2010
PubMed
Summary

MicroRNAs (miRNAs) are RNA molecules involved in tumor development. The miR-17-19 cluster shows dual roles as oncogenes and antioncogenes, impacting cancer progression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Context:

  • MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression.
  • Dysregulation of miRNA pathways is implicated in various human cancers.
  • The miR-17-19 cluster is frequently altered in tumors.

Purpose:

  • To review the mechanisms and functions of the miR-17-19 cluster in tumorigenesis.
  • To elucidate the dual oncogenic and antioncogenic roles of miR-17-19.
  • To summarize current understanding of miRNA involvement in cancer.

Summary:

  • MiRNAs regulate target genes within signaling pathways, influencing tumor initiation and progression.
  • The miR-17-19 cluster acts as both an oncogene and an antioncogene, depending on the cellular context.

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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

  • This cluster's dysregulation is a significant factor in oncogenesis.

    • Impact:

    • Understanding the miR-17-19 cluster's function can reveal novel therapeutic targets for cancer.
    • This review provides insights into miRNA-based cancer diagnostics and treatments.
    • Highlights the complex role of specific miRNA clusters in cancer biology.