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Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

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Related Experiment Video

Updated: Jun 6, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Antibiotic heterogeneity.

Robert G Masterton1

  • 1The Ayr Hospital, UK. robert.masterton@aaaht.scot.nhs.uk

International Journal of Antimicrobial Agents
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

Antibiotic heterogeneity offers a promising strategy in sepsis management to combat rising antimicrobial resistance. This approach helps preserve antibiotic effectiveness by strategically deploying different drug classes.

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Last Updated: Jun 6, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • Rising antimicrobial resistance (AMR) is a critical global health threat impacting sepsis management.
  • Antibiotic stewardship programs are essential for optimizing antimicrobial use and preserving drug efficacy.
  • Traditional strategies like antibiotic cycling are being re-evaluated in light of evolving resistance patterns.

Purpose of the Study:

  • To explore the potential of antibiotic heterogeneity as a strategy to mitigate antimicrobial resistance in sepsis.
  • To evaluate the shift in focus from antibiotic cycling to antibiotic heterogeneity in stewardship research.
  • To highlight the clinical implications of antibiotic heterogeneity in preserving the effectiveness of existing antimicrobial classes.

Main Methods:

  • Review of mathematical modeling studies on antibiotic class deployment.
  • Analysis of emerging clinical data on antibiotic heterogeneity.
  • Comparative assessment of antibiotic cycling and heterogeneity strategies.

Main Results:

  • Mathematical modeling consistently supports structured approaches to antibiotic class use.
  • A recent shift in research focus from antibiotic cycling to antibiotic heterogeneity is observed.
  • Preliminary clinical data suggest antibiotic heterogeneity is an attractive strategy for preserving antimicrobial effectiveness.

Conclusions:

  • Antibiotic heterogeneity presents a viable and attractive option for antibiotic stewardship in sepsis.
  • This strategy aims to delay the emergence of resistance by optimizing the deployment of available antibiotic classes.
  • Further clinical research is needed to fully establish the role and efficacy of antibiotic heterogeneity in sepsis management.