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[Breast cancer with axillary lymph node involvement].

A Belaid1, S Kanoun, A Kallel

  • 1Département de radiothérapie, Unité fonctionnelle de Sénologie, institut Gustave-Roussy, Villejuif, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 7, 2010
PubMed
Summary

Breast cancer with axillary nodal involvement requires post-operative radiation therapy (XRT) for reduced recurrence and mortality. This review outlines 3D-conformal treatment planning for locally advanced breast cancers, considering key organs at risk.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Medical Imaging

Context:

  • Breast cancer is the most common cancer in women globally, with over a million new cases annually.
  • Axillary nodal involvement is present in over half of breast cancer cases, impacting treatment decisions.
  • Post-operative radiation therapy (XRT) significantly reduces locoregional recurrence and mortality in these patients.

Purpose:

  • To review the epidemiological, radioanatomic, and prognostic factors of breast cancer with axillary nodal involvement.
  • To propose guidelines for 3D-conformal radiation therapy planning in locally advanced breast cancers.
  • To provide a comprehensive overview for clinicians managing this patient population.

Summary:

  • Breast cancer with axillary nodal involvement necessitates post-operative radiation therapy (XRT) for improved outcomes.
  • 3D-conformal irradiation planning involves defining target volumes (chest wall, breast, tumor bed, nodal areas) and critical organs at risk (lung, heart, brachial plexus).
  • This review details treatment planning considerations for locally advanced breast cancers with nodal involvement.

Impact:

  • Optimized 3D-conformal treatment planning can enhance the efficacy of radiation therapy for breast cancer patients with nodal involvement.
  • Improved understanding of radioanatomic features and prognostic factors can lead to more personalized treatment strategies.
  • This review serves as a valuable resource for oncologists and radiation therapists, potentially improving patient survival and quality of life.