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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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[Non-hodgkin's lymphomas].

F Drouet1, X Cahu, Y Pointreau

  • 1Service de radiothérapie du centre rené-gauducheau, CRLCC Nantes-Atlantique, Boulevard Jacques-Monod, 44805 Saint-Herblain cedex, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

Radiotherapy plays a role in treating non-Hodgkin's lymphoma (NHL), particularly localized aggressive subtypes like Diffuse Large B-Cell Lymphoma (DLBCL) and indolent lymphomas. It also offers palliative care for symptomatic bulky tumors across all NHL types.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Hematology
  • Oncology
  • Radiation Oncology

Background:

  • Non-Hodgkin's lymphoma (NHL) is a common hematological malignancy in France, comprising diverse lymphoproliferative diseases.
  • NHLS are broadly categorized into aggressive (e.g., Diffuse Large B-Cell Lymphoma - DLBCL) and indolent (e.g., follicular, MALT lymphomas) subtypes with distinct characteristics.
  • Radiotherapy's role in NHL management has evolved, becoming more specialized over time.

Observation:

  • Radiotherapy is indicated with curative intent for localized aggressive NHLs, often combined with chemotherapy for DLBCL.
  • Exclusive radiotherapy is used for rare cases of localized indolent lymphomas, such as follicular lymphomas.
  • Lymphocytes' radiosensitivity makes radiotherapy valuable for palliative management of symptomatic bulky NHL masses, irrespective of subtype.

Findings:

  • The "Involved Field" irradiation remains a standard for nodal NHL, though newer techniques aim to minimize irradiated tissue and reduce complications.
  • Understanding the specific epidemiological, radio-anatomical, and prognostic features of each NHL subtype is crucial for optimal radiotherapy planning.
  • This article details these aspects for various NHL subtypes (excluding primary CNS lymphomas) and illustrates practical radiotherapy modalities with a clinical case.

Implications:

  • Optimized radiotherapy strategies can improve outcomes for localized NHL while minimizing long-term side effects.
  • Tailoring treatment based on NHL subtype and disease characteristics is essential for effective management.
  • Further research into advanced irradiation techniques may enhance the safety and efficacy of radiotherapy in NHL treatment.