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Updated: Jun 6, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
["Evidence-based medicine" and "mixed methods": how methodological discussions in the medical and social sciences
1Fakultät für Geistes- und Sozialwissenschaften, Helmut-Schmidt-Universität Hamburg, Hamburg. kelle@hsu-hh.de
Abstract:
The debate about adequate research methods for obtaining relevant results in clinical medicine and health care does not take place in a vacuum. In the present paper the longstanding debate about the epistemological underpinnings and methodological perspectives of qualitative and quantitative research methods in the social sciences is outlined and fructified for evidence-based medicine and health care. By using examples from research practice we will demonstrate that both the utilisation of qualitative methods and the use of a "mixed methods" design may contribute to the current methodological debate and improve research practice in evidence-based health care.
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