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Development of long-acting nitrate delivery systems.

U E Jonsson1

  • 1Pharmaceutical Research and Development, AB Hässle, Mölndal, Sweden.

European Journal of Clinical Pharmacology
|January 1, 1990
PubMed
Summary

This review covers long-acting nitrate delivery systems, focusing on pharmaceutical and biopharmaceutical development. It highlights recent advancements in transdermal nitroglycerin and oral controlled-release isosorbide-5-mononitrate formulations.

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Area of Science:

  • Pharmaceutical Science
  • Biopharmaceutical Development
  • Drug Delivery Systems

Background:

  • Nitrate formulations are crucial for managing cardiovascular conditions.
  • Developing long-acting nitrate delivery systems presents unique pharmaceutical and biopharmaceutical challenges.
  • Controlled release of nitrates is essential for therapeutic efficacy and patient compliance.

Purpose of the Study:

  • To review pharmaceutical and biopharmaceutical aspects of long-acting nitrate delivery system development.
  • To discuss fundamental considerations and requirements for these systems.
  • To present recent product development activities in this field.

Main Methods:

  • Literature review of pharmaceutical and biopharmaceutical research.
  • Analysis of product development activities for nitrate formulations.
  • Focus on transdermal and oral controlled-release systems.

Main Results:

  • Key pharmaceutical and biopharmaceutical considerations for long-acting nitrates are outlined.
  • Recent developments in transdermal nitroglycerin systems are discussed.
  • Oral controlled-release formulations of isosorbide-5-mononitrate are presented.

Conclusions:

  • Successful development of long-acting nitrate delivery systems requires careful attention to pharmaceutical and biopharmaceutical factors.
  • Transdermal nitroglycerin and oral controlled-release isosorbide-5-mononitrate represent significant advancements.
  • Further innovation in controlled-release technologies is vital for optimizing nitrate therapy.

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