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Updated: Jun 6, 2026
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Reproducibility of reported in utero exposure to tobacco smoke
Lea A Cupul-Uicab1, Xibiao Ye, Rolv Skjaerven
1Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Human and Health Services, Durham, NC 27709, USA. cupuluicabl@niehs.nih.gov
Purpose:
In studies of the fetal origins of disease and life course epidemiology, measures of fetal exposure may be based on information reported by the adults who were exposed in utero. In particular, the full spectrum of consequences of in utero exposure to maternal tobacco smoking is now an area of active investigation, and the ability to report such exposure reproducibly is of interest. We evaluated the reproducibility of in utero exposure to tobacco smoke, reported by the adult daughter during consecutive pregnancies.
Methods:
This study was based on 11,257 women who enrolled for more than one pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Participants completed a questionnaire around 17 weeks of gestation, which asked about their in utero exposure to tobacco smoke. Kappa statistics were calculated. Determinants of agreement were evaluated using logistic regression.
Results:
Weighted Kappa for in utero exposure for the first and second reports was 0.80. Determinants of agreement were higher education (better) and longer time between reports (worse).
Conclusions:
Information on in utero exposure to maternal tobacco smoking provided by adult women was highly reproducible in this population.
