Related Experiment Video

Updated: Jun 6, 2026

Structured Motor Rehabilitation After Selective Nerve Transfers
09:34

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

Can every patient be mobilized?

John F DiPersio1

  • 1Washington University School of Medicine, St Louis, Missouri 63110, United States. jdipers@dom.wustl.edu

Best Practice & Research. Clinical Haematology
|December 7, 2010
PubMed

There are several ways to mobilize hematopoietic stem cells for autologous and allogeneic hematopoietic stem cell transplant by manipulating the bone marrow microenvironment. Granulocyte colony-stimulating factor (G-CSF) and chemotherapy have been commonly used to mobilize stem cells, but several new agents, such as the CXCR4 inhibitor plerixafor, inhibit stromal-stem cell interactions to improve stem cell yield. The minimum threshold for engraftment is 2 × 10⁶ CD34+ cells/kg, but it has been shown that higher CD34+ stem cell dose, such as 5 × 10⁶ CD34+ cells/kg, is associated with improved survival. Efforts to increase stem cell yield remain important to improve outcomes.

More Related Videos

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis08:55

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

Related Concept Videos

Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...