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Published on: July 28, 2016
Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis
Mohamamd Naderi1, Mohammad Hashemi, Fatemeh Komijani-Bozchaloei
1Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Background:
The aim of the present study was to determine serum paraoxonase and arylesterase activities in tuberculosis, nontuberculosis pulmonary disease and healthy subjects.
Materials And Methods:
In this case-control study we determined the serum paraoxonase and arylesterase activities in 36 patients with pulmonary tuberculosis, 38 nontuberculosis pulmonary disease and 49 healthy controls.
Results:
The results showed that serum paraoxonase (PON) activity was significantly lower in patients with pulmonary tuberculosis (61.10±51.62IU/L) than healthy controls (98.79±68.79IU/L) (p<0.05). In addition we found that the level of PON activity was significantly lower in patients with nontuberculosis pulmonary disease (67.49±47.88IU/L) than normal individuals (p<0.05). There was no significant differences regarding PON activity between patients with pulmonary tuberculosis and nontuberculosis pulmonary disease (p>0.05). The arylesterase activity was significantly lower in patients with pulmonary tuberculosis than nontuberculosis pulmonary disease and normal subjects (p<0.05).
Discussion:
The lower paraoxonase and aryesterase activities in pulmonary tuberculosis patients compared to healthy subjects might be due to imbalance of oxidant/antioxidant systems in pulmonary tuberculosis patients which needs more clarification.
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