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Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Standing Waves01:17

Standing Waves

Sometimes waves do not seem to move; rather, they just vibrate in place. Unmoving waves can be seen on the surface of a glass of milk kept in a refrigerator, which is one example of standing waves. Vibrations from the refrigerator motor create waves on the milk that oscillate up and down but do not seem to move across the surface. These waves are formed or created by the superposition of two or more identical moving waves in opposite directions. The waves move through each other, with their...

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Updated: Jun 6, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
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Published on: January 7, 2020

miRNAs got rhythm.

Terry S Elton1, Mickey M Martin, Sarah E Sansom

  • 1Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA. terry.elton@osumc.edu

Life Sciences
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators of cardiac function and disease. This review explores their role in cardiac arrhythmia and therapeutic potential for treatment.

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Area of Science:

  • Molecular Biology
  • Cardiology
  • Genetics

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality, necessitating novel therapeutic strategies.
  • Understanding molecular mechanisms of cardiac function is crucial for developing effective CVD treatments.
  • MicroRNAs (miRNAs) are small non-coding RNAs regulating cardiac and vascular development and disease.

Purpose of the Study:

  • To summarize the mechanisms of microRNA action in cardiac arrhythmia.
  • To explore the therapeutic potential of microRNAs in treating cardiac arrhythmias.

Main Methods:

  • Literature review summarizing miRNA biogenesis and function.
  • Focus on miRNA regulatory roles in cardiac arrhythmia pathways.
  • Analysis of miRNA-based therapeutic strategies for arrhythmias.

Main Results:

  • MicroRNAs regulate gene expression by targeting messenger RNAs (mRNAs) via the miRNA-induced silencing complex (miRISC).
  • Specific miRNAs are implicated in cardiac arrhythmia, fibrosis, hypertrophy, ischemia, heart failure, and atherosclerosis.
  • miRNA seed regions (nucleotides 2-8) are critical for target mRNA recognition in the 3'-untranslated region (3'-UTR).

Conclusions:

  • MicroRNAs are critical regulators in cardiac pathophysiology, particularly in arrhythmias.
  • miRNAs offer promising therapeutic targets for the management of cardiac arrhythmias.
  • Further research into miRNA mechanisms can drive innovation in cardiovascular medicine.