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Updated: Jun 6, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
Published on: November 19, 2013
Whole genome association scan for genetic polymorphisms influencing information processing speed
Michelle Luciano1, Narelle K Hansell, Jari Lahti
1Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Scotland, UK. michelle.luciano@ed.ac.uk
This study identified genes and biological pathways influencing cognitive processing speed across diverse age groups. Findings may advance understanding of psychiatric disorders and aging.
Area of Science:
- Cognitive neuroscience
- Genetics
- Psychiatry
Background:
- Cognitive processing speed declines with age and is impaired in psychiatric conditions like schizophrenia and depression.
- Processing speed shares genetic links with complex cognitive functions such as working memory and reasoning.
Purpose of the Study:
- To identify genes associated with cognitive processing speed.
- To explore biological pathways implicated in processing speed variations.
Main Methods:
- Genome-wide association scan (GWAS) was conducted across four cohorts with varying mean ages.
- Meta-analysis of single nucleotide polymorphisms (SNPs) and pathway analyses using KEGG and Gene Ontology (GO) databases were performed.
Main Results:
- Suggestively significant SNPs and candidate genes, including TRIB3, were identified.
- Pathway analysis revealed common pathways such as cell junction and focal adhesion (KEGG), and receptor binding and cellular metabolic process (GO).
Conclusions:
- The identified genes and pathways provide valuable insights into the genetic architecture of processing speed.
- These findings can inform future research on cognitive aging and psychiatric disorders.
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