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Updated: Jun 6, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
Adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling by angiotensin II
Marcel Egger1, Andrea A Domenighetti
1Department of Physiology, University of Bern, CH-3012 Bern, Switzerland. egger@pyl.unibe.ch
Abstract:
Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling are not precisely known. We review this question, as well as acute Ang II-mediated modulation of ECC. In addition, we discuss adaptive/maladaptive modulation of cardiomyocyte ECC under chronic endogenous Ang II overproduction in the heart induced by local overexpression of the of the renin-angiotensin system in the mouse.
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