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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Ocular complications in patients with lung transplants
Ahmad B Tarabishy1, Omar F Khatib, John R Nocero
1Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
The British Journal of Ophthalmology
|December 7, 2010
Summary
Lung transplant recipients can develop various eye problems. Infectious ocular complications are rare but linked to higher mortality rates, emphasizing the need for vigilant monitoring.
Area of Science:
- Ophthalmology
- Transplantation Medicine
- Infectious Diseases
Background:
- Lung transplantation is a life-saving procedure for end-stage lung disease.
- Post-transplant patients are at risk for various complications, including ocular issues.
- Ocular complications can impact patient quality of life and survival.
Purpose of the Study:
- To investigate the spectrum of infectious and non-infectious ocular complications in lung transplant recipients.
- To identify risk factors and outcomes associated with these ocular complications.
Main Methods:
- Retrospective analysis of 46 lung transplant patients who underwent ophthalmologic examination.
- Review of patient diagnoses, treatments, immune status, and survival data.
- Correlation analysis between ocular findings and clinical parameters.
Main Results:
- Posterior subcapsular cataract was the most frequent ocular finding (28.3%).
- Infectious ocular complications occurred in 13.0% of patients, including fungal and viral infections.
- Infectious complications were associated with decreased absolute lymphocyte count and a high mortality rate (5/6 patients died within 6 months).
Conclusions:
- Lung transplant recipients are susceptible to a range of ocular conditions.
- Ocular infections, though uncommon, represent a significant risk factor for mortality in this population.
- Regular ophthalmic surveillance is crucial for early detection and management of ocular complications.
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