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Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity

Jeremy P Wood1, Jay R Silveira, Nicole M Maille

  • 1Department of Biochemistry, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA.

Blood
|December 7, 2010
PubMed
Summary

Activated platelets form alpha-thrombin through a specific pathway, initially cleaving prothrombin at Arg271 to generate prethrombin-2, which optimizes clotting and limits anticoagulant effects.

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