Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stable β2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes.

European journal of immunology·2026
Same author

Clinical outcomes of sub-millisievert CT evaluation of congenital chest wall deformity using photon counting CT: a new standard of care?

Research square·2026
Same author

Thromboelastography Associates to Decreased Plasma Transfusions in the Medical Intensive Care Unit: A Retrospective Study.

Critical care research and practice·2026
Same author

Comparative Effectiveness of Upadacitinib vs. Other JAK Inhibitors in Patients With Rheumatoid Arthritis in a Global Real-World Setting.

Rheumatology and therapy·2026
Same author

Association of blood pressure variability with clinical and biomarker outcomes in moderate to severe TBI: A TRACK-TBI study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Early Autonomic Dysfunction After Severe Traumatic Brain Injury: A Brief Report.

Anesthesia and analgesia·2026
Same journal

Response to Ortiz-Santiago et al: Reasons for Ordering a Computed Tomography Scan and Abnormalities Found in Pediatric Intermediate-Risk Mild Head Trauma.

Pediatric emergency care·2026
Same journal

Response to Ortiz-Santiago et al, "Reasons for Ordering a Computed Tomography Scan and Abnormalities Found in Pediatric Intermediate-Risk Mild Head Trauma".

Pediatric emergency care·2026
Same journal

Improving Emergency Care for Children With Medical Complexity: A Pragmatic Review.

Pediatric emergency care·2026
Same journal

Comparison of a Pediatric Emergency Care Database and the Pediatric Health Information System.

Pediatric emergency care·2026
Same journal

How Accurate Is Point-of-Care Ultrasound for Detecting Pediatric Elbow Fractures Presenting to the Emergency Department?: A Systematic Review and Meta-Analysis.

Pediatric emergency care·2026
Same journal

Etiologic Diversity and Diagnostic Yield of Multiplex PCR in Children With Bloody Diarrhea: A Prospective Study in a Pediatric Emergency Department.

Pediatric emergency care·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Pediatric cannabinoid hyperemesis: two cases.

Joseph B Miller1, Mark Walsh, Pankaj A Patel

  • 1Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202, USA. jmiller6@hfhs.org

Pediatric Emergency Care
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

Cannabinoid hyperemesis syndrome, a condition linked to chronic marijuana use, is now described in pediatric patients. Symptoms like severe nausea and vomiting resolved after patients stopped using marijuana.

More Related Videos

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Related Experiment Videos

Last Updated: Jun 6, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Area of Science:

  • Gastroenterology
  • Toxicology
  • Pediatrics

Background:

  • Cannabinoid hyperemesis syndrome (CHS) is a recently identified condition associated with chronic marijuana use.
  • The syndrome is characterized by recurrent episodes of severe nausea, vomiting, and abdominal pain.
  • Previously, CHS has been documented exclusively in adult populations.

Observation:

  • This report details two pediatric cases presenting with symptoms consistent with CHS.
  • Both patients underwent comprehensive gastrointestinal evaluations, which did not reveal an underlying organic cause.
  • A notable behavioral symptom, compulsive bathing, was observed in both pediatric patients, mirroring adult case reports.

Findings:

  • The diagnosis of cannabinoid hyperemesis syndrome was established in two pediatric patients.
  • Cessation of marijuana use led to the complete resolution of symptoms in both cases.
  • The findings suggest that CHS can occur in adolescent populations, not just adults.

Implications:

  • This study expands the known demographic of cannabinoid hyperemesis syndrome to include pediatric patients.
  • It highlights the importance of considering CHS in the differential diagnosis of unexplained chronic nausea and vomiting in children and adolescents with a history of marijuana use.
  • Further research is warranted to understand the long-term effects and prevalence of CHS in younger individuals.