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Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Coagulation01:09

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Related Experiment Video

Updated: Jun 6, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Cell-derived microparticles promote coagulation after moderate exercise.

Maik Sossdorf1, Gordon P Otto, Ralf A Claus

  • 1Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, and Department of Sports Medicine, Institute of Sports Science, Jena Friedrich-Schiller University, Jena, Germany. maik.sossdorf@med.uni-jena.de

Medicine and Science in Sports and Exercise
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

Exercise increases procoagulant microparticles (MP) in healthy individuals, impacting blood hemostasis. Trained individuals show faster clearance of these MP compared to untrained individuals after exercise.

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Microfluidics in Assessing Platelet Function
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Area of Science:

  • Exercise physiology
  • Hemostasis
  • Biomedical science

Background:

  • Cell-derived procoagulant microparticles (MP) play a role in blood hemostasis.
  • Exercise can influence hemostatic parameters.

Purpose of the Study:

  • To investigate the concentration and procoagulant activity of cell-derived MP after moderate endurance exercise.
  • To compare MP release, clearance, and activity in trained versus untrained individuals post-exercise.

Main Methods:

  • Subjects performed 90 minutes of cycling exercise at 80% of anaerobic threshold.
  • Microparticles (MP) were quantified using flow cytometry.
  • Procoagulant activity was assessed via prothrombinase assay and tissue factor-induced fibrin formation.

Main Results:

  • Exercise significantly increased MP levels (platelet, monocyte, endothelial) in trained subjects, returning to baseline within 2 hours.
  • Untrained subjects showed elevated platelet-derived MP levels for up to 2 hours post-exercise, indicating reduced clearance.
  • Procoagulant activity of MP increased immediately post-exercise and remained elevated for 2 hours in all subjects.

Conclusions:

  • Acute exercise increases circulating MP levels in healthy individuals, enhancing hemostatic potential.
  • Trained individuals exhibit distinct MP kinetics, including faster clearance, compared to untrained individuals.
  • Microparticle dynamics and activity are altered by exercise, with notable differences between fitness levels.