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Updated: Jun 6, 2026
05:56
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
Delayed emesis: moderately emetogenic chemotherapy (single-day chemotherapy regimens only)
Fausto Roila1, David Warr, Matti Aapro
1S. Maria Hospital, Terni, Italy. roila.fausto@libero.it
Summary
For chemotherapy-induced nausea, aprepitant is recommended for delayed emesis when combined with anthracycline and cyclophosphamide. If aprepitant is not used, multiday dexamethasone is preferred for delayed emesis prevention.
Area of Science:
- Oncology
- Pharmacology
Background:
- Chemotherapy-induced nausea and vomiting (CINV) remains a significant challenge for patients undergoing cancer treatment.
- Updated guidelines are crucial for managing delayed emesis, particularly with moderately emetogenic chemotherapy regimens.
Framework:
- The third Perugia Consensus Conference (June 2009) updated recommendations for preventing delayed emesis.
- A systematic review of randomized controlled studies published since April 2004 informed the consensus.
Implementation:
- Nine studies were reviewed, focusing on NK1 receptor antagonists, palonosetron, and dopamine receptor antagonists.
- Recommendations address prophylaxis for delayed emesis in patients receiving anthracycline plus cyclophosphamide chemotherapy.
Implications:
- Aprepitant is suggested for delayed emesis prevention in specific chemotherapy regimens.
- Multiday oral dexamethasone is recommended when aprepitant is not administered and palonosetron is used.
- Both recommendations carry moderate levels of evidence and consensus.
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