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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

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Related Experiment Video

Updated: Jun 6, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Anabolic agents and bone quality.

Tarek Sibai1, Elise F Morgan, Thomas A Einhorn

  • 1Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118, USA.

Clinical Orthopaedics and Related Research
|December 7, 2010
PubMed
Summary
This summary is machine-generated.

This review explores anabolic agents for improving bone quality, including parathyroid hormone and potential new drugs. Future research aims to enhance bone health management through novel treatments and delivery systems.

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Last Updated: Jun 6, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

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09:43

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11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

  • Pharmacology
  • Orthopedics
  • Biochemistry

Background:

  • Bone quality is increasingly defined by anabolic agents that improve bone mineral density, microarchitecture, and remodeling.
  • This evolving definition considers multiple facets of bone health beyond simple density measurements.

Purpose of the Study:

  • To review molecular pathways and physiological effects of current and potential anabolic drugs for bone quality.
  • To provide an overview of therapeutic strategies targeting bone anabolic processes.

Main Methods:

  • A MEDLINE search (1996-2010) identified articles on "bone quality" combined with terms like "anabolic agent," "parathyroid hormone," "strontium ranelate," "prostaglandin," and "statin."
  • A secondary search focused on novel potential anabolic agents.

Main Results:

  • Parathyroid hormone is the sole FDA-approved anabolic agent in the US, with extensive research supporting its use.
  • Strontium ranelate is approved in Europe; prostaglandin agonists lack human trials; statins show promise but have limited bone bioavailability.
  • Emerging pathways like PYK2 and sclerostin (SOST) inhibition are under investigation.

Conclusions:

  • Continued research into enhancing current anabolic agents and discovering new ones is crucial.
  • Developing improved drug delivery systems will significantly advance the management of bone quality-related conditions.
  • These advancements promise better future treatments for bone injuries and diseases.