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Related Concept Videos

Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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[Does rheopheresis reduce the cardiovascular risk?].

Alfonso Ramunni1, Maria Burzio, Lucia Verno'

  • 1Nefrologia I, Policlinico Consorziale , Bari, Italy. a.ramunni@nephro.uniba.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|December 7, 2010
PubMed
Summary

Rheopheresis, including LDL apheresis, protects blood vessels by removing harmful proteins and improving blood flow. This therapy offers rapid clinical benefits, particularly for microcirculation issues.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Nephrology

Context:

  • Rheopheresis encompasses apheresis techniques like double filtration plasmapheresis, LDL apheresis, and fibrinogen apheresis.
  • These procedures remove high molecular weight proteins, offering vascular protection.
  • LDL apheresis, in particular, combats endothelial dysfunction by reducing inflammatory and procoagulant factors.

Purpose:

  • To elucidate the mechanisms by which rheopheresis protects vascular walls.
  • To highlight the hemorheological improvements and clinical efficacy of rheopheresis.
  • To explore the short-term and long-term effects of rheopheresis on vascular damage.

Summary:

  • Rheopheresis improves vascular health by reducing circulating proteins, enhancing vasodilation, and decreasing blood viscosity.
  • It positively impacts hemorheology, improving microcirculatory perfusion.
  • Clinical benefits are observed rapidly, particularly in conditions affecting the microcirculation such as ischemic optic neuropathy, sudden hearing loss, and peripheral arterial disease.

Impact:

  • Rheopheresis demonstrates significant efficacy in improving microcirculation and correcting functional vascular alterations.
  • While short-term functional improvements may be temporary, long-term benefits on morphological vascular damage have been documented.
  • Further research is needed to identify the primary mechanism of vascular protection, including potential roles for endothelial progenitor cells.