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Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

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Published on: June 2, 2023

Surface charge-dependent toxicity of silver nanoparticles.

Amro M El Badawy¹, Rendahandi G Silva, Brian Morris

¹Department of Civil & Environmental Engineering, University of Cincinnati, Cincinnati, Ohio, USA.

Environmental Science & Technology

|December 8, 2010

Summary

The surface charge of silver nanoparticles (AgNPs) significantly influences their environmental toxicity. This study demonstrates that AgNP toxicity to bacillus species is primarily governed by surface charge, not just size or shape.

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Published on: May 10, 2018

Area of Science:

Environmental Science
Nanotechnology
Microbiology

Background:

Silver nanoparticles (AgNPs) have widespread applications, raising concerns about their environmental impact.
Previous studies indicate AgNP toxicity depends on factors like size, shape, and capping agents.

Purpose of the Study:

To investigate the influence of surface charge on AgNP toxicity.
To evaluate the toxicity of four AgNPs with varying surface charges: uncoated, citrate-coated, PVP-coated, and BPEI-coated.

Main Methods:

Investigated toxicity of four AgNPs with distinct surface charges (negative to positive).
Utilized ultrafiltration to purify AgNP suspensions, removing impurities for accurate toxicity assessment.
Assessed AgNP toxicity on specific bacillus species.

Main Results:

AgNP toxicity was demonstrably dependent on surface charge.
Highly positive surface charges correlated with increased toxicity to bacillus species.
Ultrafiltration purification was critical for reliable toxicity data.

Conclusions:

Surface charge is a dominant factor in AgNP toxicity to microorganisms.
Accurate assessment of AgNP environmental risks requires consideration of surface charge and purification methods.
Standardized purification protocols are needed for reproducible AgNP toxicity studies.